The Bruno Mars-assisted track racked up a huge chart tally of 118,000 following its early release on Monday evening, comprising of 105,000 downloads and 1.35 million streams.
The feat bests his previous peak of Number 2 with singles Stop Me and Amy Winehouse collaboration Valerie, both of which were released in 2007.
Mark told OfficialCharts.com: "This is my first Number 1 single as an artist or producer so I just want to thank everyone who bought, downloaded or DJ'd 'Uptown Funk' this past week.
"It's pretty much the coolest thing ever. I also have to thank Phil Smeeze, Jeff Bhasker and the boy wonder Bruno Mars without whom there'd be no jam."
Uptown Funk’s impressive sales now puts it firmly in the running to take on this week’s Official Christmas Number 1 race, where it will where it will fight it out for the accolade with the likes of Band Aid 30, Iron Maiden and this year’s X Factor winner. Check out the full list of contenders here.
Meanwhile, last week’s Number 1 Thinking Out Loud from Ed Sheeran slips to 2, and Band Aid 30’s Do They Know It’s Christmas? jumps 12 to 3 following its physical release this week.
Take That’s These Days is at Number 4, and Oliver Heldens’ Last All Night (Koala) – the follow-up to his Number 1 single Gecko (Overdrive) – is a new entry and Number 5.
New entries and high climbers
One Direction climb 19 to 7 to earn their 11th Top 10 single with Night Changes, The Pogues’ Fairytale Of New York leaps 18 to 11, and Mariah Carey’s All I Want For Christmas Is You – the third most-streamed track of the week with 1.13 million streams - is at 16.
Elsewhere, Sheffield rockers Bring Me The Horizon score their first ever UK Top 40 hit with Drown at Number 17, and US girl group Fifth Harmony are new at 21 with Bo$$.
|1||UPTOWN FUNK||MARK RONSON FT BRUNO MARS|
|2||THINKING OUT LOUD||ED SHEERAN|
|3||DO THEY KNOW IT'S CHRISTMAS||BAND AID 30|
|4||THESE DAYS||TAKE THAT|
|5||LAST ALL NIGHT (KOALA)||OLIVER HELDENS FT KSTEWART|
|6||BLANK SPACE||TAYLOR SWIFT|
|7||NIGHT CHANGES||ONE DIRECTION|
|8||WRAPPED UP||OLLY MURS FT TRAVIE MCCOY|
|9||OUTSIDE||CALVIN HARRIS/ELLIE GOULDING|
|10||REAL LOVE||CLEAN BANDIT FT JESS GLYNNE|
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